SW 837 (ABC-TC1191)

Human Caucasian rectum adenocarcinoma. Established from a Grade IV adenocarcinoma of the rectum of a 53 year old Caucasian male. The cells produce CEA and electron microscopy reveals brush borders.<Br />
The cells are negative for expression of CSAp (CSAp-) and colon antigen 3, negative. There is a C -&gt; T mutation in codon 248 of the p53 gene resulting in an Arg -&gt; Trp substitution. The cells are positive for keratin by immunoperoxidase staining.