Staurosporine (SM97-5)

Staurosporine is a potent inhibitor of phospholipid/calcium-dependent protein kinase. It also inhibits the upregulation of VEGF expression in tumor cells. It partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. It inhibits Pgp phosphorylation. It is also a broad spectrum inhibitor of serine/threonine kinases.