Rapamycin (SM83-100)

Rapamycin is a specific inhibitor of mTOR (mammalian target of Rapamycin). It forms a complex with FKBP12 that binds to and inhibits mTOR. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity.