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Migration Inhibitory Factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin-1 (IL-1), interleukin-8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-γ-activated macrophages, MIF stimulates nitric oxide (NO) production and Tumor Necrosis Factor α (TNF-α) secretion.
