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BIRB796 (SM11-25)
BIRB796 is a protein kinase inhibitor of p38 MAPK. BIRB796 has high picomolar affinity for p38 MAP kinase and low nanomolar inhibitory activity against TNF-alpha in THP-1 cell culture. The p38 inhibitor BIRB796 binds tightly to ABL(T315I) and inhibits the BMS-354825 and imatinib-resistant ABL(T315I) kinase.
