ALK5 Inhibitor II (SM09-50)

ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50 = 23 nM, 4 nM and 18 nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF-β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK.