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EDITGENE開發了CRISPR-EDITx TM 平台和Bingo TM prime編輯點突變平台，為各科研機構和企業提供了數百項CRO服務（基因敲除、過度表現、內源點突變和CRISPR文庫篩選等）。推動CRISPR/Cas技術的應用。
在分子診斷方面，我們的技術團隊開發了更好的Cas12和Cas13蛋白純化平台，並發現了最佳的crRNA設計原理。由此，我們建立了FASST檢測技術，並大幅提升了CRISPR檢測的靈敏度。
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[Cutting Edge] CRISPR Updates: CRISPR/Cas9 Gene Knockout Technology Helps Develop New Methods to Eradicate Cancer Cells
I.Research News
(Ⅰ)CRISPR Gene Knockout Cells
Researchers at the Shanghai Institute of Silicate, Chinese Academy of Sciences, have recently developed a magnetothermal-induced CRISPR-Cas9 gene editing system to target the knockout of HSP70 and BCL2 genes. This novel approach aims to ablate cancer cells while sparing adjacent healthy cells.
The magnetothermal nanoparticle platform enables plasmid DNA loading, and under the influence of a controlled alternating magnetic field, the mild magnetothermal effect (42°C) not only triggers dual genome editing to disrupt the tumor cells’ apoptosis resistance mechanisms but also makes the tumor cells more sensitive to apoptosis through the thermal effect itself, achieving a synergistic therapeutic effect.
This research was recently published in the Journal of Nanobiotechnology under the title “Magnetothermal-activated gene editing strategy for enhanced tumor cell apoptosis.”
Original Article Link：https://doi.org/10.1186/s12951-024-02734-8
CRISPR/Cas technology is a revolutionary tool in modern bioscience, with applications expanding into medicine, agriculture, ecological conservation, and more. The “CRISPR Weekly News” section brings you the latest research and industry news. Below is a brief summary of last week’s top headlines:
Research Updates
CRISPR Screening
Title:CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells
Journal: Nature (Impact Factor: 50.5)
Original Link: https://doi.org/10.1038/s41586-024-07972-2
Aging impairs neural stem cell activity in the adult mammalian brain. Researchers conducted a genome-wide CRISPR screen on primary neural stem cells from young and aged mice, identifying over 300 genes whose knockout specifically restored the activity of aged neural stem cells. The study highlighted glucose metabolism as a key factor in this process, with Slc2a4 (encoding GLUT4 glucose transporter) knockout showing the most significant results. This research offers a platform to systematically identify genetic interventions that enhance aged neural stem cell function, providing important insights for combating regenerative decline during aging.
Title:A genome-wide CRISPR/Cas9 knockout screen identifies SEMA3F gene for resistance to cyclin-dependent kinase 4 and 6 inhibitors in breast cancer