{"id":198814,"date":"2022-03-10T16:50:27","date_gmt":"2022-03-10T08:50:27","guid":{"rendered":"https:\/\/www.interlabbiotech.com\/wp\/product\/highqc-human-ipsc-derived-neural-stem-cell-mapt-r406w-hom"},"modified":"2022-03-10T16:50:30","modified_gmt":"2022-03-10T08:50:30","slug":"highqc-human-ipsc-derived-neural-stem-cell-mapt-r406w-hom","status":"publish","type":"product","link":"https:\/\/www.interlabbiotech.com\/wp\/product\/highqc-human-ipsc-derived-neural-stem-cell-mapt-r406w-hom","title":{"rendered":"HighQC\u2122 Human IPSC-Derived Neural Stem Cell MAPT R406W HOM (ABC-SC0069T)"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>Human Human IPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the R406W mutation (CGG&amp;gt;TGG) into the MAPT gene. This line is homozygous for the R406W mutation so both alleles contain the mutation.<br \/>\nThe R406W mutation in MAPT has been implicated in familial frontotemporal dementia and parkinsonism (Hutton et al., 1998; Behnam et al., 2015) and has been seen in patients with clinical presentation resembling Alzheimer&#8217;s disease (Rademakers et al., 2003; Lindquist et al., 2008). The R406W mutation reduces the ability of MAPT\/tau to bind to microtubules in vitro (Hong et al., 1998).<\/p>\n","protected":false},"featured_media":191157,"template":"","meta":[],"product_brand":[],"product_cat":[312445,315266],"product_tag":[],"class_list":{"0":"post-198814","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-accegen","7":"product_cat-cell-lines","8":"pa_category-2-stem-cells","9":"pa_product-name-highqc-human-ipsc-derived-neural-stem-cell-mapt-r406w-hom","10":"pa_product-no-abc-sc0069t","11":"pa_shipping-info-dry-ice","12":"pa_size-1-vial","13":"pa_species-human","14":"pa_storage-liquid-nitrogen","15":"pa_supplier-company-accegen-biotechnology","17":"first","18":"instock","19":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/product\/198814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/media\/191157"}],"wp:attachment":[{"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/media?parent=198814"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/product_brand?post=198814"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/product_cat?post=198814"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.interlabbiotech.com\/wp\/wp-json\/wp\/v2\/product_tag?post=198814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}